I don't know what the doctor will do, if he will lower the dose or try that dose again, it's whatever Mayo tells him. He just follows their plan so he will talk to them. He told me I wouldn't feel the greatest so I wasn't surprised but I didn't expect it to be quite as bad. I'm better today, I can't say I feel TERRIBLE, I'll be taking a nap but on really bad days I am almost not up at all. When I say I felt bad, I just mean that extreme fatigue, not sleepy but bone tired. I did LOVE last night, I slept like a log and normally I hardly sleep at all on Wednesday night. The doctor seemed very surprised that I had gone so long without the low blood counts, did I say that both red and white cells were down along with everything else that had to do with the condition of my blood. I hope to feel a bit better each day now and for SURE I hope to feel a lot better than I normally would on a Friday!!